Blogs

Colorful Hematology: How stains reveal cellular morphology

Colorful Hematology: How stains reveal cellular morphology

Date: July 1, 2025

Author: Jacek Lesinski

In modern hematology, advanced diagnostic methods such as flow cytometry, cytogenetics, and molecular diagnostics are increasingly replacing traditional stains. While these methods offer high specificity and sensitivity, cytochemical stains remain...

Uncovering a rare case of Acute Monocytic Leukemia: Can you spot the promonocytes in a blood smear?

Uncovering a rare case of Acute Monocytic Leukemia: Can you spot the promonocytes in a blood smear?

Date: June 2, 2025

Author: Dr. Chaitra C, M.D. Pathology

Acute monocytic leukemia is a rare and aggressive subtype of acute myeloid leukemia with monocytic differentiation. Accurate identification of promonocytes as blast equivalents and their inclusion in the blast count...

Caught in the bloodline: unraveling Thalassemia

Caught in the bloodline: unraveling Thalassemia

Date: May 16, 2025

Author: Dr. Sharitha Naganna, M.D. Pathology

Thalassemia is the most common genetic and hereditary blood disorder affecting the global population. It is caused by unbalanced production of globin chains, leading to ineffective erythropoiesis. It is prevalent...

Beyond the hairy cells: Decoding hairy cell leukemia

Beyond the hairy cells: Decoding hairy cell leukemia

Date: May 1, 2025

Author: Dr. Pavithra Devi. N, M.D. Pathology

Hairy cell leukemia(HCL) is a type of chronic lymphoproliferative disorder (CLPD) and a neoplasm of the mutant mature memory B cells. It occurs in middle-aged to elderly individuals with a...

The ticking time bomb: Understanding acute promyelocytic leukemia from a pathologist’s lens

The ticking time bomb: Understanding acute promyelocytic leukemia from a pathologist’s lens

Date: April 15, 2025

Author: Dr. Gayathri Talapula, M.D. Pathology

Acute Promyelocytic Leukemia(APL) is a highly curable and distinct variant of acute myeloid leukemia, caused by t(15;17) translocation leading to the generation of the PML-RARA fusion protein. Early treatment with...

RBC inclusions unveiled: Why peripheral smear still matters?

RBC inclusions unveiled: Why peripheral smear still matters?

Date: April 1, 2025

Author: Dr. Sharitha Naganna, M.D. Pathology

With the advent of reliable automated hematology analyzers, the role of peripheral smear examination has become increasingly limited. However, certain cellular abnormalities can only be identified through manual smear review...

Malaria on the peripheral smear: A pathologist’s guide to morphological identification

Malaria on the peripheral smear: A pathologist’s guide to morphological identification

Date: March 15, 2025

Author: Dr. Chaitra C, M.D. Pathology

Malaria is an endemic vector-borne parasitic disease caused by the protozoa of the genus Plasmodium, occurring in tropical and subtropical regions. A misdiagnosed infection can progress to severe anaemia and...

Plasma cell leukemia- what’s new? what’s obsolete?

Plasma cell leukemia- what’s new? what’s obsolete?

Date: February 28, 2025

Author: Dr. Pavithra Devi. N, M.D. Pathology

Plasma cell leukemia (PCL) is an aggressive and rare hematological malignancy with a poor prognosis. The diagnostic criterion was revised by the International Myeloma Working Group (IMWG) in 2021 from...

Blasts and their morphological variants — Does morphology matter in the molecular era?

Blasts and their morphological variants — Does morphology matter in the molecular era?

Date: February 14, 2025

Author: Dr. Chaitra C, M.D. Pathology

Blasts are immature cells. They are usually not seen in the blood of normal healthy people and are seen in leukemias, myelodysplastic syndrome (MDS), and myelodysplastic neoplasms (MPN). Evaluating the...

Bent but unbroken: Comprehensive review of sickle cell anemia

Bent but unbroken: Comprehensive review of sickle cell anemia

Date: February 11, 2025

Author: Dr. Gayathri Talapula, M.D. Pathology

Sickle cell anemia (SCA) is a relatively common hereditary hemoglobinopathy with abnormal hemoglobin S production, leading to distorted RBC morphology, chronic hemolytic anemia, and complications involving many systems in the...

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